In a mixing bowl, combine the shredded chicken, mashed avocado, Greek yogurt, Dijon mustard, lime juice, garlic powder, onion powder, salt, and pepper. Mix until well combined and creamy.
Lay out the lettuce leaves on a clean surface.
Spoon an equal amount of the chicken salad mixture onto each lettuce leaf.
Top each with cherry tomatoes, red onion, and cilantro.
Roll up the lettuce leaves tightly to enclose the filling and secure with a toothpick if needed.
Serve immediately or refrigerate for up to 30 minutes before serving for a chilled option.