Bring a large pot of salted water to a boil. Add the linguini and cook according to package instructions until al dente. Reserve 1/2 cup of pasta water, then drain the pasta and set aside.
In a large skillet over medium heat, heat the olive oil. Add the minced garlic and red pepper flakes, sautéing for about 1 minute until fragrant but not browned.
Pour in the white wine and bring to a simmer. Let it cook for about 2-3 minutes to reduce slightly.
Add the clams to the skillet, cover, and cook for about 5-7 minutes, or until the clams have opened. Discard any clams that do not open.
Stir in the cooked linguini and reserved pasta water. Toss everything together until well combined. Season with salt and pepper to taste.
Remove from heat and stir in the chopped parsley. Serve immediately with lemon wedges on the side.