Place the chicken breasts in the bottom of the slow cooker. Season with salt, pepper, chili powder, garlic powder, onion powder, and smoked paprika.
Add the drained corn and diced tomatoes with green chilies on top of the chicken.
Spread the softened cream cheese over the corn and tomatoes.
Cover the slow cooker and cook on low for 6-8 hours or on high for 3-4 hours, until the chicken is cooked through and easily shreds with a fork.
Once cooked, shred the chicken in the slow cooker using two forks and mix everything together.
Stir in the shredded cheddar cheese until melted and well combined.
Serve hot, garnished with fresh cilantro and lime wedges on the side.